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1V-LSD (1-Valeroyl-d-lysergic acid diethylamide or Valerie), is a substance of the Lysergamide class. It is closely related to LSD and 1P-LSD.
1V-LSD’s inventor is unknown. There is no reference to 1V-LSD in any scientific or academic literature prior to it becoming available online in 2021. All Lysergamides are isolated from a fungus called ergo. Ergot contains compounds known as ergot alkaloids, each of which contains a system called the tetracyclic ergoline ring system. Modifying the ergoline ring system creates new compounds that produce different effects. 1V-LSD is named for the valeryl group bound to the nitrogen of the polycyclic indole group of LSD. The tetracyclic ergoline is characteristic of the chemical structure of ergot alkaloids.
In contrast to LSD, 1V-LSD has an additional N1-valeryl group, which is where it gets its nickname, Valerie. This makes them structurally different from one another.
Chemical modifications in the N1 position are among the most frequently performed on this class of drugs. The Drug Enforcement Agency predicted this kind of chemical synthesis as early as the 1980s. They knew chemists could alter chemicals by adding or removing specific groups of atoms and thereby producing substances with similar chemical structures. Essentially, 1V-LSD is similar but with the addition of a valeryl group which is attached to the nitrogen of LSD’s polycyclic indole group.